Familiar Job, Novel Setting

Going into today I felt simultaneously that I had a fair amount of experience to bank on, and that I was totally unprepared for spending a day with HIV counselors who would test and counsel mothers and their young children. As a SHAC HIV counselor I have never tested or counseled children or their parents, and I have been lucky enough to have never had a positive. Going into today I knew the former was a definite and suspected the latter would occur before the day was out.

I started my day in the inpatient wards. The team of counselors, Gift, Effie, Lonely, and Gertrude who I worked with (more explanation of Malawian names later) are charged with testing pediatric inpatients who are referred by clinicians, whose mother’s have been identified as HIV+ at intake, or who meet certain clinical criteria. Before the day started Gift introduced me to the other counselors and then helped me practice some of my Chichewa. I learned (and then promptly forgot) how to say “I am going home.” I’m not sure what it means that this was the phrase I was taught at the beginning of the day, but things preceded better than they might have given that start.

In testing children for HIV there are several unique considerations: the first is determining the mother’s HIV status. Of the fifteen (or so) women who we counseled this morning, about three were known to be HIV positive. For these mothers there is a risk (I believe around 10-15%) that they transmitted the virus to their child during delivery, and a continued risk of transmitting the virus through breastfeeding. Interestingly, while there is an increased risk of transmitting HIV during breastfeeding, even over delivery itself, breastfeeding is still recommended for the first year of life.

The reason for this recommendation is that malnutrition in the first six months is a much greater threat to children than HIV transmitted from mother to child, especially if the mother is on antiretroviral therapy. Previous guidelines said to wean children from breast feeding at six months, yet it was found that children weaned at this interval had a high death rate due to malnutrition, and yet still had a high risk of mother-to-child transmission (MTCT) because the solid foods were causing micro tears in the infant’s stomach that, when breast milk was given, allowed the virus to enter their circulation. The recommendation has thus been amended to delay weaning to one year which has been shown to reduce risk of both malnourishment and MTCT.  This example is illustrative of the complexities of practicing medicine in such a limited-resource setting. The best intentions can be completely confounded by the overwhelming disease burden of the population.

In addition to learning the ins and out of pediatric testing and counseling, it was interesting to see some of the organizational differences between SHAC HIV testing and testing at KCH. KCH employs a group pre-test counseling session with individual post-test counseling sessions. This allows counselors to test a higher volume of patients, and may have the added benefit of normalizing testing without revealing too much personal information, though as other counselors, hospital personnel and other patients often barged in on pre- and post-test counseling confidentiality was certain lacking in both the inpatient and outpatient wards.

I asked one of the counselors whether people had upset reactions to positive test. She told me no, people just accept it. When I’m counseling a patient in Durham who tells me about high risk behaviors, and I being to suspect they are infected I feel a panic start to rise. Of course, it is my job as a counselor to push the panic down and help the patient deal with the test results. Yet, I found that when HIV+ mothers came in with their newly delivered infants that panic didn’t rise. It was as if I too had somehow come to just accept it. I’m not sure what this means. We didn’t deliver a single positive result today; I suspect doing so would have provoked a much more emotional response on my behalf. But I am still left wondering what it means about me that I didn’t have ‘the panic.’ Am I becoming hardened? Or did I simply adapt?

24 Hours in Lilongwe

Well, I have arrived! After an uneventful but l-o-n-g series of plane rides we got to Lilongwe around 1 pm Malawi time (6 hours ahead of EST) yesterday. Friday was a busy day! Upon our arrival, Mariah, Timica (the two other UNC med students) and I came to the UNC guesthouse. The guesthouse is where visiting UNC researchers, physicians and students stay. I’ve never stayed in such modern facilities in the ‘developing world’ and I find myself feeling both pleased and awkward/guilty. Much of the culture shock that I have experienced on previous trips abroad has been due to adjusting to cold showers, toilets that don’t flush and co-inhabiting rodents. Here at the guesthouse there is wi-fi, cable and plenty of hot water to go around. I think all of these amenities will help make the transition easier, and will enable me to be more productive on the actual work. It does, however, make me feel uncomfortable to be living such an American lifestyle when Malawi, as a country, is so poor. Knowing all of the good work the UNC Project does helps assuage some of these feelings, but they persist none the less. I’m sure this is just a drop in the bucket in terms of the moral and ethical quandaries that this trip will bring up so I will leave that for now to report on the rest of the day.

One great thing about the UNC guesthouse is that it practically shares a campus with Kamuzu Central Hospital (KCH) and the Baylor Lighthouse facility (for pediatric HIV/AIDS treatment) so after dropping our bags we walked over to KCH to meet our future colleagues and supervisors. During my meeting, I found out that my two supervisors (one from UNC, one from Baylor) will both be gone for the first few weeks of my stay. Thankfully, they have worked out a schedule for me to do rotations on the pediatric wards of KCH, Lighthouse and some outpatient clinics so that by the time my research work begins I will have a good idea of what goes on in all of the facilities where we will be working.

In speaking with other people working at KCH, I heard of the familiar ups and downs of research in the ‘developing world.’ A common frustration was difficulty getting IRB approval on the Malawian side (as I understand it, all projects must be approved by the researcher’s home institution and by a Malawian IRB). I also heard of problems I became familiar with while working in Nicaragua: scheduling meetings that no one attends, problems with staff and patient participation etc. My research in Nicaragua taught me that, as much as possible, the most productive way to deal with these issues is not fight them but try to work with them (eg. incentivize attendance and participation) or when all else fails, just go with the flow. While it may not be official data collection, you can often learn as much from talking to the people around you as you can in administering a survey.  Hopefully once I get actual assignments and deadlines I can keep this laid-back attitude.

After our meetings at KCH, Mariah and I went for a short jog to work out some of the kinks we acquired on the plane. The weather here is perfect for outdoor exercise, mid 70s in the day and mid 40s at night. When we started our run we heard the call to prayer from a mosque in Old Town, Lilongwe; Malawi has a significant Muslim population. It’s the first time I’ve ever lived somewhere with this custom, and I find hearing the call five times a day quite beautiful.

Last night we had Indian food for dinner; there is also a sizable Indian population in Malawi (keep your eyes out for an upcoming “About Malawi” page that will have more exhaustive information on the people and culture of Malawi.) Then we headed off to a farewell party for one of the Infectious Disease Fellows who has been working here for the past two years.

This was my first introduction to the large and active ex-pat community in Malawi. This is a phenomenon that I haven’t encountered before with such force. Like living in the guesthouse, there are certain benefits to having a social circle of people who enjoy activities such as running, yoga,  and cooking Westernized dinners, that Malawians may be more hesitant to engage in. It is also nice to know there are people who approach this experience with similar perspectives. However, it seems counterintuitive for me to travel all the way to Malawi and work on a project that directly relates to the behavioral habits and well-being of Malawian people only to then spend my time hanging out exclusively with Europeans, Americans and Aussies. For me, it brings up many questions of socioeconomics and race that are difficult to enumerate and even more difficult to resolve.  For fear of this becoming a never-ending post I won’t elaborate on those now, but expect to dedicate at least  full posts to some of these issues down the road.

Post-party I slept for 12.5 hours and awoke feeling refreshed and ready to take on my first full day in Malawi. One of my major goals for my first two weeks here is getting the traditional Malawian greeting down. While many people here speak English, Chichewa is the native language. In Chichewa you never just say “hi” the exchange (in Chichewa) is as follows:

Muli bwanji?  How are you?
Ndili bwino, kaya inu? I am fine. How are you?
Ndlili bwino, zicomo. I am fine thanks.
Zikomo kwamberia. Thank you very much.

There are different variations on this depending on time of day, and infinite ways you can alter it depending on the person you are addressing. For now, I’m just trying to learn the most generic version. So far I can get the first line out if I am the one initiating the conversation. If I don’t initiate, I get completely thrown off and reply in some incomprehensible mumble-jumble. This is why I am also focusing on ‘zikomo’ which means thank you and ‘pepani’ which means sorry/excuse me. I find these phrases are almost always considered polite. 

I have also found that running is an excellent time to practice. I call out “Muli bwanjni” as I pass and by the time that it is my turn to respond I am long gone. On second thought, this may not be the best practice but it boosts my morale as I run along calling out a greeting in Chichewa and then motivates me to run quickly before the ‘conversation’ comes to the part where I should respond “ndili bwino, zikomo” -which I find very difficult to pronounce.

After an afternoon of shopping for vegetables and chitengas (spelling approximated), the traditional fabrics Malawian women use as wraps and to carry their babies, I’m back at the guesthouse trying to learn Chichewa and rest up for another full day. So for now I’ll say tsalani bwino! (Stay well)

T-Minus Two Days

Hello (soon-to-be) loyal readers!

Now that the whirl-wind that was the first year of medical school is done, I have time and energy to focus my energies on my next adventure: a summer of research in Malawi! This new-found time and energy is just in the nick of time, too, because I take off in exactly 48 hours and 30 minutes!

In Malawi I will be working with the UNC Project, a partnership between the Univeristy of North Carolina and the Malawian Ministry of Health. As such, I will be working with investigators from Baylor University and University of North Carolina to test a new method of diagnosing HIV in neonates.

Traditional HIV tests, which look for antibodies to the virus, cannot be used in children under 18 months because maternal antibodies which are acquired during gestation and delivery are still presesnt in the newborn (potentially giving false positives). This presents a problem because it has been found that if parents of potentially HIV-positive newborns take their children home, they may not have the ability, resources, or desire to return for testing 18 months later.

Thus to effectively initiate antiretroviral therapy (ART) in HIV+ newborns researchers and clinicians need to overcome a public health problem and a diagnositc problem. Clinicians need a diagnostic tool that doesn't look for antibodies and they need a tool that can be used at point-of-care (POC) so that the families don't have to return to the hopsital. The test that we will be evaluating this summer has already been shown to be diagnostically useful, it is called the p24 assay and it looks for a viral protein, which will only be present in children who are themselves HIV+, regardless of the maternal antibodies they carry. The study will also evaluate various manners of administering the test, in terms of which hospital personell are responsible, how the lab work is divided amongst responsible parties etc. The ultimate goal will be to find the most efficient way to identify HIV-positive newborns in order to initiate ART.

Contrary to what was believed in the early days of the HIV epidemic, it is now generally accepted that early initiation of ART therapy is critical to the patient's prognosis and can help sustain CD4 counts and prolong life expectancy. Thus this is an issue of critical importance to the estimated 91,000 Malawian children living with HIV.

While I have a background in HIV-related research in the 'developing world' and currently serve as an HIV testing counselor through the UNC student clinic, SHAC, I anticipate that this summer will be full of new lessons and new challenges. I am looking forward to learning about Malawian people and culture, putting the skills I learned this year into use, and contributing to an important project that has the potential to vastly improve the prognosis for children born with HIV in Malawi.

I'm thrilled and honored to be working with some of the best, brightest and most dedicated in this field, and alongside two of my classmates who are as committed and excited as I am. I'm glad that you all will be joining me on my adventures, some of you actively and some of you vicariously. As the summer progresses and I learn more about blogging I hope to improve the look of the blog and provide pictures, info on Malawi and more about the project. I look forward to your questions and comments and sharing what I'm sure is going to be a great experience with you!